| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 22/04/25 23:00 | Alianza Lima | CA Talleres | Group D | 3-2 |
| 22/04/25 23:00 | LDU Quito | Flamengo | Group C | 0-0 |
| 22/04/25 23:00 | Carabobo FC | Universidad de Chile | Group A | 1-1 |
| 23/04/25 01:30 | Internacional | Club Nacional de Football | Group F | 3-3 |
| 23/04/25 01:30 | Colo-Colo | Racing Club | Group E | 1-1 |
| 23/04/25 03:00 | Barcelona SC | Universitario | Group B | 0-1 |
| 23/04/25 23:00 | Club Olimpia | Club Atlético Peñarol | Group H | 0-0 |
| 23/04/25 23:00 | San Antonio Bulo Bulo | CA Velez Sarsfield | Group H | 2-1 |
| 24/04/25 01:30 | Club Libertad | FC Sao Paulo | Group D | 0-2 |
| 24/04/25 01:30 | Independiente del Valle | River Plate | Group B | 2-2 |
| 24/04/25 01:30 | Estudiantes de La Plata | Botafogo | Group A | 1-0 |
| 24/04/25 03:00 | Atlético Bucaramanga | Fortaleza | Group E | 1-1 |
| 24/04/25 23:00 | Club Bolívar | Palmeiras | Group G | 2-3 |
| 24/04/25 23:00 | Central Cordoba | Deportivo Tachira | Group C | 2-1 |
| 25/04/25 01:00 | Bahia BA | Atlético Nacional | Group F | 1-0 |
| 25/04/25 01:30 | Club Cerro Porteno | Sporting Cristal | Group G | 2-2 |