| Date | Home | Away | Result |
|---|---|---|---|
| 06/11/25 17:45 | Samsunspor | Hamrun Spartans | 3-0 |
| 06/11/25 17:45 | Schachtjor Donezk | Breidablik Kopavogur | 2-0 |
| 06/11/25 17:45 | Sparta Prag | KS Rakow Czestochowa | 0-0 |
| 06/11/25 17:45 | NK Celje | Legia Warschau | 2-1 |
| 06/11/25 17:45 | Kuopion PS | SK Slovan Bratislava | 3-1 |
| 06/11/25 17:45 | AEK Athens | Shamrock Rovers | 1-1 |
| 06/11/25 17:45 | AEK Larnaka | FC Aberdeen | 0-0 |
| 06/11/25 17:45 | FC Noah | Sigma Olomouc | 1-2 |
| 06/11/25 17:45 | FSV Mainz 05 | Fiorentina | 2-1 |
| 06/11/25 20:00 | SK Rapid Wien | Universitatea Craiova | 0-1 |
| 06/11/25 20:00 | Dynamo Kiew | HŠK Zrinjski Mostar | 6-0 |
| 06/11/25 20:00 | Crystal Palace | AZ Alkmaar | 3-1 |
| 06/11/25 20:00 | Rayo Vallecano | Lech Poznan | 3-2 |
| 06/11/25 20:00 | Lincoln Red Imps FC | HNK Rijeka | 1-1 |
| 06/11/25 20:00 | KF Shkendija | Jagiellonia Bialystok | 1-1 |
| 06/11/25 20:00 | BK Häcken | Racing Club Strasbourg | 1-2 |
| 06/11/25 20:00 | FC Lausanne-Sport | Omonia Nicosia | 1-1 |
| 06/11/25 20:00 | FC Shelbourne | KF Drita Gjilan | 0-1 |