| Date | Home | Away | Result |
|---|---|---|---|
| 21/10/25 17:45 | FC Barcelona | Olympiakos Piräus | 6-1 |
| 21/10/25 17:45 | Kairat Almaty | Pafos FC | 0-0 |
| 21/10/25 20:00 | PSV Eindhoven | SSC Napoli | 6-2 |
| 21/10/25 20:00 | FC Villarreal | Manchester City | 0-2 |
| 21/10/25 20:00 | FC Copenhagen | Borussia Dortmund | 2-4 |
| 21/10/25 20:00 | Royale Union Saint-Gilloise | Inter Milan | 0-4 |
| 21/10/25 20:00 | Arsenal FC | Atletico Madrid | 4-0 |
| 21/10/25 20:00 | Newcastle United | Benfica Lisbon | 3-0 |
| 21/10/25 20:00 | Bayer 04 Leverkusen | Paris St. Germain | 2-7 |
| 22/10/25 17:45 | Galatasaray Istanbul | FK Bodö/Glimt | 3-1 |
| 22/10/25 17:45 | Athletic Bilbao | Qarabag | 3-1 |
| 22/10/25 20:00 | Real Madrid | Juventus Turin | 1-0 |
| 22/10/25 20:00 | FC Bayern Munich | Club Brugge | 4-0 |
| 22/10/25 20:00 | Chelsea FC | Ajax Amsterdam | 5-1 |
| 22/10/25 20:00 | Eintracht Frankfurt | Liverpool FC | 1-5 |
| 22/10/25 20:00 | Atalanta Bergamo | Slavia Prag | 0-0 |
| 22/10/25 20:00 | Sporting Lisbon | Olympique Marseille | 2-1 |
| 22/10/25 20:00 | AS Monaco | Tottenham Hotspur | 0-0 |