| Date | Home | Away | Result |
|---|---|---|---|
| 09/12/25 15:30 | Kairat Almaty | Olympiakos Piräus | 0-1 |
| 09/12/25 17:45 | FC Bayern Munich | Sporting Lisbon | 3-1 |
| 09/12/25 20:00 | AS Monaco | Galatasaray Istanbul | 1-0 |
| 09/12/25 20:00 | FC Barcelona | Eintracht Frankfurt | 2-1 |
| 09/12/25 20:00 | PSV Eindhoven | Atletico Madrid | 2-3 |
| 09/12/25 20:00 | Atalanta Bergamo | Chelsea FC | 2-1 |
| 09/12/25 20:00 | Tottenham Hotspur | Slavia Prag | 3-0 |
| 09/12/25 20:00 | Royale Union Saint-Gilloise | Olympique Marseille | 2-3 |
| 09/12/25 20:00 | Inter Milan | Liverpool FC | 0-1 |
| 10/12/25 17:45 | FC Villarreal | FC Copenhagen | 2-3 |
| 10/12/25 17:45 | Qarabag | Ajax Amsterdam | 2-4 |
| 10/12/25 20:00 | Athletic Bilbao | Paris St. Germain | 0-0 |
| 10/12/25 20:00 | Bayer 04 Leverkusen | Newcastle United | 2-2 |
| 10/12/25 20:00 | Borussia Dortmund | FK Bodö/Glimt | 2-2 |
| 10/12/25 20:00 | Club Brugge | Arsenal FC | 0-3 |
| 10/12/25 20:00 | Juventus Turin | Pafos FC | 2-0 |
| 10/12/25 20:00 | Real Madrid | Manchester City | 1-2 |
| 10/12/25 20:00 | Benfica Lisbon | SSC Napoli | 2-0 |