| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 15/05/22 14:30 | 15/05/22 14:15 | Werder Bremen | Jahn Regensburg | 2-0 | 2 - 4 points |
| 15/05/22 14:30 | 15/05/22 14:15 | SV Darmstadt 98 | SC Paderborn 07 | 3-0 | 2 - 4 points |
| 15/05/22 14:30 | 15/05/22 14:15 | 1. FC Heidenheim 1846 | Karlsruher SC | 2-0 | 2 - 4 points |
| 15/05/22 14:30 | 15/05/22 14:15 | FC St. Pauli | Fortuna Düsseldorf | 2-0 | 2 - 4 points |
| 15/05/22 14:30 | 15/05/22 14:15 | 1. FC Nürnberg | FC Schalke 04 | 1-2 | 2 - 4 points |
| 15/05/22 14:30 | 15/05/22 14:15 | Hannover 96 | FC Ingolstadt | 3-2 | 2 - 4 points |
| 15/05/22 14:30 | 15/05/22 14:15 | SV Sandhausen | Holstein Kiel | 3-1 | 2 - 4 points |
| 15/05/22 14:30 | 15/05/22 14:15 | Dynamo Dresden | Erzgebirge Aue | 0-1 | 2 - 4 points |
| 15/05/22 14:30 | 15/05/22 14:15 | FC Hansa Rostock | Hamburger SV | 2-3 | 2 - 4 points |