| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 09/09/22 17:30 | 09/09/22 17:15 | 1. FC Nürnberg | Arminia Bielefeld | 1-0 | 2 - 4 points |
| 09/09/22 17:30 | 09/09/22 17:15 | Holstein Kiel | Hamburger SV | 2-3 | 2 - 4 points |
| 10/09/22 12:00 | 10/09/22 11:45 | Karlsruher SC | 1. FC Heidenheim 1846 | 0-0 | 2 - 4 points |
| 10/09/22 12:00 | 10/09/22 11:45 | Hannover 96 | Eintracht Braunschweig | 1-1 | 2 - 4 points |
| 10/09/22 12:00 | 10/09/22 11:45 | SC Paderborn 07 | Jahn Regensburg | 3-0 | 2 - 4 points |
| 10/09/22 19:30 | 10/09/22 19:15 | Fortuna Düsseldorf | FC Hansa Rostock | 3-1 | 2 - 4 points |
| 11/09/22 12:30 | 11/09/22 12:15 | 1. FC Magdeburg | SpVgg Greuther Fürth | 2-1 | 2 - 4 points |
| 11/09/22 12:30 | 11/09/22 12:15 | FC St. Pauli | SV Sandhausen | 1-1 | 2 - 4 points |
| 11/09/22 12:30 | 11/09/22 12:15 | 1. FC Kaiserslautern | SV Darmstadt 98 | 3-3 | 2 - 4 points |