Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| 2.BL | 17/09/21 17:30 | 17/09/21 17:20 | 1. FC Nürnberg | FC Hansa Rostock | 1-0 | 1 - 3 points |
| 2.BL | 17/09/21 17:30 | 17/09/21 17:20 | FC Schalke 04 | Karlsruher SC | 1-2 | 1 - 3 points |
| GER1 | 17/09/21 19:30 | 17/09/21 19:20 | Hertha BSC | SpVgg Greuther Fürth | 2-1 | 3 - 5 points |
| 2.BL | 18/09/21 12:30 | 18/09/21 12:20 | Fortuna Düsseldorf | Jahn Regensburg | 1-1 | 1 - 3 points |
| 2.BL | 18/09/21 12:30 | 18/09/21 12:20 | SV Sandhausen | 1. FC Heidenheim 1846 | 1-3 | 1 - 3 points |
| 2.BL | 18/09/21 12:30 | 18/09/21 12:20 | Holstein Kiel | Hannover 96 | 0-3 | 1 - 3 points |
| GER1 | 18/09/21 14:30 | 18/09/21 14:20 | FC Bayern Munich | VfL Bochum | 7-0 | 3 - 5 points |
| GER1 | 18/09/21 14:30 | 18/09/21 14:20 | Arminia Bielefeld | 1899 Hoffenheim | 0-0 | 3 - 5 points |
| GER1 | 18/09/21 14:30 | 18/09/21 14:20 | FC Augsburg | Bor. Mönchengladbach | 1-0 | 3 - 5 points |
| GER1 | 18/09/21 14:30 | 18/09/21 14:20 | FSV Mainz 05 | SC Freiburg | 0-0 | 3 - 5 points |
| GER1 | 18/09/21 17:30 | 18/09/21 17:20 | 1. FC Köln | RB Leipzig | 1-1 | 3 - 5 points |
| 2.BL | 18/09/21 19:30 | 18/09/21 19:20 | Werder Bremen | Hamburger SV | 0-2 | 1 - 3 points |
| 2.BL | 19/09/21 12:30 | 19/09/21 12:20 | SV Darmstadt 98 | Dynamo Dresden | 1-0 | 1 - 3 points |
| 2.BL | 19/09/21 12:30 | 19/09/21 12:20 | FC St. Pauli | FC Ingolstadt | 4-1 | 1 - 3 points |
| 2.BL | 19/09/21 12:30 | 19/09/21 12:20 | Erzgebirge Aue | SC Paderborn 07 | 1-4 | 1 - 3 points |
| GER1 | 19/09/21 14:30 | 19/09/21 14:20 | VfB Stuttgart | Bayer 04 Leverkusen | 1-3 | 3 - 5 points |
| GER1 | 19/09/21 16:30 | 19/09/21 16:20 | Borussia Dortmund | 1. FC Union Berlin | 4-2 | 3 - 5 points |
| GER1 | 19/09/21 18:30 | 19/09/21 18:20 | VfL Wolfsburg | Eintracht Frankfurt | 1-1 | 3 - 5 points |