Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| 2.BL | 27/08/21 17:30 | 27/08/21 17:20 | SV Sandhausen | FC Ingolstadt | 0-2 | 1 - 3 points |
| 2.BL | 27/08/21 17:30 | 27/08/21 17:20 | 1. FC Nürnberg | Karlsruher SC | 2-1 | 1 - 3 points |
| GER1 | 27/08/21 19:30 | 27/08/21 19:20 | Borussia Dortmund | 1899 Hoffenheim | 3-2 | 3 - 5 points |
| 2.BL | 28/08/21 12:30 | 28/08/21 12:20 | Holstein Kiel | Erzgebirge Aue | 3-0 | 1 - 3 points |
| 2.BL | 28/08/21 12:30 | 28/08/21 12:20 | SV Darmstadt 98 | Hannover 96 | 4-0 | 1 - 3 points |
| 2.BL | 28/08/21 12:30 | 28/08/21 12:20 | 1. FC Heidenheim 1846 | Hamburger SV | 0-0 | 1 - 3 points |
| GER1 | 28/08/21 14:30 | 28/08/21 14:20 | FC Augsburg | Bayer 04 Leverkusen | 1-4 | 3 - 5 points |
| GER1 | 28/08/21 14:30 | 28/08/21 14:20 | FSV Mainz 05 | SpVgg Greuther Fürth | 3-0 | 3 - 5 points |
| GER1 | 28/08/21 14:30 | 28/08/21 14:20 | VfB Stuttgart | SC Freiburg | 2-3 | 3 - 5 points |
| GER1 | 28/08/21 14:30 | 28/08/21 14:20 | 1. FC Köln | VfL Bochum | 2-1 | 3 - 5 points |
| GER1 | 28/08/21 14:30 | 28/08/21 14:20 | Arminia Bielefeld | Eintracht Frankfurt | 1-1 | 3 - 5 points |
| GER1 | 28/08/21 17:30 | 28/08/21 17:20 | FC Bayern Munich | Hertha BSC | 5-0 | 3 - 5 points |
| 2.BL | 28/08/21 19:30 | 28/08/21 19:20 | FC Schalke 04 | Fortuna Düsseldorf | 3-1 | 1 - 3 points |
| 2.BL | 29/08/21 12:30 | 29/08/21 12:20 | Dynamo Dresden | SC Paderborn 07 | 0-3 | 1 - 3 points |
| 2.BL | 29/08/21 12:30 | 29/08/21 12:20 | Werder Bremen | FC Hansa Rostock | 3-0 | 1 - 3 points |
| 2.BL | 29/08/21 12:30 | 29/08/21 12:20 | FC St. Pauli | Jahn Regensburg | 2-0 | 1 - 3 points |
| GER1 | 29/08/21 14:30 | 29/08/21 14:20 | 1. FC Union Berlin | Bor. Mönchengladbach | 2-1 | 3 - 5 points |
| GER1 | 29/08/21 16:30 | 29/08/21 16:20 | VfL Wolfsburg | RB Leipzig | 1-0 | 3 - 5 points |