Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| 2.BL | 20/08/21 17:30 | 20/08/21 17:20 | Fortuna Düsseldorf | Holstein Kiel | 2-2 | 1 - 3 points |
| 2.BL | 20/08/21 17:30 | 20/08/21 17:20 | Hannover 96 | 1. FC Heidenheim 1846 | 1-0 | 1 - 3 points |
| GER1 | 20/08/21 19:30 | 20/08/21 19:20 | RB Leipzig | VfB Stuttgart | 4-0 | 3 - 5 points |
| 2.BL | 21/08/21 12:30 | 21/08/21 12:20 | Karlsruher SC | Werder Bremen | 0-0 | 1 - 3 points |
| 2.BL | 21/08/21 12:30 | 21/08/21 12:20 | SC Paderborn 07 | FC St. Pauli | 3-1 | 1 - 3 points |
| 2.BL | 21/08/21 12:30 | 21/08/21 12:20 | Jahn Regensburg | FC Schalke 04 | 4-1 | 1 - 3 points |
| GER1 | 21/08/21 14:30 | 21/08/21 14:20 | SpVgg Greuther Fürth | Arminia Bielefeld | 1-1 | 3 - 5 points |
| GER1 | 21/08/21 14:30 | 21/08/21 14:20 | VfL Bochum | FSV Mainz 05 | 2-0 | 3 - 5 points |
| GER1 | 21/08/21 14:30 | 21/08/21 14:20 | SC Freiburg | Borussia Dortmund | 2-1 | 3 - 5 points |
| GER1 | 21/08/21 14:30 | 21/08/21 14:20 | Eintracht Frankfurt | FC Augsburg | 0-0 | 3 - 5 points |
| GER1 | 21/08/21 14:35 | 21/08/21 14:25 | Hertha BSC | VfL Wolfsburg | 1-2 | 3 - 5 points |
| GER1 | 21/08/21 17:30 | 21/08/21 17:20 | Bayer 04 Leverkusen | Bor. Mönchengladbach | 4-0 | 3 - 5 points |
| 2.BL | 21/08/21 19:30 | 21/08/21 19:20 | FC Hansa Rostock | Dynamo Dresden | 1-3 | 1 - 3 points |
| 2.BL | 22/08/21 12:30 | 22/08/21 12:20 | Erzgebirge Aue | SV Sandhausen | 1-3 | 1 - 3 points |
| 2.BL | 22/08/21 12:30 | 22/08/21 12:20 | FC Ingolstadt | 1. FC Nürnberg | 0-0 | 1 - 3 points |
| 2.BL | 22/08/21 12:30 | 22/08/21 12:20 | Hamburger SV | SV Darmstadt 98 | 2-2 | 1 - 3 points |
| GER1 | 22/08/21 14:30 | 22/08/21 14:20 | 1899 Hoffenheim | 1. FC Union Berlin | 2-2 | 3 - 5 points |
| GER1 | 22/08/21 16:30 | 22/08/21 16:20 | FC Bayern Munich | 1. FC Köln | 3-2 | 3 - 5 points |