Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| 2.BL | 10/12/21 17:30 | 10/12/21 17:20 | FC Schalke 04 | 1. FC Nürnberg | 4-1 | 1 - 3 points |
| 2.BL | 10/12/21 17:30 | 10/12/21 17:20 | Jahn Regensburg | Werder Bremen | 2-3 | 1 - 3 points |
| GER1 | 10/12/21 19:30 | 10/12/21 19:20 | 1. FC Köln | FC Augsburg | 0-2 | 3 - 5 points |
| 2.BL | 11/12/21 12:30 | 11/12/21 12:20 | Holstein Kiel | SV Sandhausen | 2-2 | 1 - 3 points |
| 2.BL | 11/12/21 12:30 | 11/12/21 12:20 | SC Paderborn 07 | SV Darmstadt 98 | 0-1 | 1 - 3 points |
| 2.BL | 11/12/21 12:30 | 11/12/21 12:20 | FC Ingolstadt | Hannover 96 | 1-2 | 1 - 3 points |
| GER1 | 11/12/21 14:30 | 11/12/21 14:20 | RB Leipzig | Bor. Mönchengladbach | 4-1 | 3 - 5 points |
| GER1 | 11/12/21 14:30 | 11/12/21 14:20 | FC Bayern Munich | FSV Mainz 05 | 2-1 | 3 - 5 points |
| GER1 | 11/12/21 14:30 | 11/12/21 14:20 | VfL Bochum | Borussia Dortmund | 1-1 | 3 - 5 points |
| GER1 | 11/12/21 14:30 | 11/12/21 14:20 | Hertha BSC | Arminia Bielefeld | 2-0 | 3 - 5 points |
| GER1 | 11/12/21 14:30 | 11/12/21 14:20 | SC Freiburg | 1899 Hoffenheim | 1-2 | 3 - 5 points |
| GER1 | 11/12/21 17:30 | 11/12/21 17:20 | VfL Wolfsburg | VfB Stuttgart | 0-2 | 3 - 5 points |
| 2.BL | 11/12/21 19:30 | 11/12/21 19:20 | Fortuna Düsseldorf | FC St. Pauli | 1-1 | 1 - 3 points |
| 2.BL | 12/12/21 12:30 | 12/12/21 12:20 | Hamburger SV | FC Hansa Rostock | 3-0 | 1 - 3 points |
| 2.BL | 12/12/21 12:30 | 12/12/21 12:20 | Karlsruher SC | 1. FC Heidenheim 1846 | 3-2 | 1 - 3 points |
| 2.BL | 12/12/21 12:30 | 12/12/21 12:20 | Erzgebirge Aue | Dynamo Dresden | 0-1 | 1 - 3 points |
| GER1 | 12/12/21 14:30 | 12/12/21 14:20 | SpVgg Greuther Fürth | 1. FC Union Berlin | 1-0 | 3 - 5 points |
| GER1 | 12/12/21 16:30 | 12/12/21 16:20 | Eintracht Frankfurt | Bayer 04 Leverkusen | 5-2 | 3 - 5 points |
| GER1 | 14/12/21 17:30 | 14/12/21 17:20 | VfB Stuttgart | FC Bayern Munich | 0-5 | 3 - 5 points |
| GER1 | 14/12/21 19:30 | 14/12/21 19:20 | Arminia Bielefeld | VfL Bochum | 2-0 | 3 - 5 points |
| GER1 | 14/12/21 19:30 | 14/12/21 19:20 | FSV Mainz 05 | Hertha BSC | 4-0 | 3 - 5 points |
| GER1 | 14/12/21 19:30 | 14/12/21 19:20 | VfL Wolfsburg | 1. FC Köln | 2-3 | 3 - 5 points |
| GER1 | 15/12/21 17:30 | 15/12/21 17:20 | Bor. Mönchengladbach | Eintracht Frankfurt | 2-3 | 3 - 5 points |
| GER1 | 15/12/21 19:30 | 15/12/21 19:20 | FC Augsburg | RB Leipzig | 1-1 | 3 - 5 points |
| GER1 | 15/12/21 19:30 | 15/12/21 19:20 | 1. FC Union Berlin | SC Freiburg | 0-0 | 3 - 5 points |
| GER1 | 15/12/21 19:30 | 15/12/21 19:20 | Bayer 04 Leverkusen | 1899 Hoffenheim | 2-2 | 3 - 5 points |
| GER1 | 15/12/21 19:30 | 15/12/21 19:20 | Borussia Dortmund | SpVgg Greuther Fürth | 3-0 | 3 - 5 points |