| Date | Home | Away | Result |
|---|---|---|---|
| 17/10/25 19:30 | Virtus Entella | Sampdoria Genua | 3-1 |
| 18/10/25 14:00 | Frosinone Calcio | AC Monza | 0-1 |
| 18/10/25 14:00 | Pescara Calcio | Carrarese Calcio 1908 | 2-2 |
| 18/10/25 14:00 | Mantova 1911 | FC Südtirol | 1-1 |
| 18/10/25 14:00 | AC Reggiana 1919 | SSC Bari | 3-1 |
| 18/10/25 16:15 | Juve Stabia | US Avellino | 2-0 |
| 18/10/25 18:30 | Spezia Calcio | FC Cesena | 1-2 |
| 19/10/25 14:00 | Palermo FC | Modena FC | 1-1 |
| 19/10/25 16:15 | FC Empoli | FC Venice | 1-1 |
| 19/10/25 18:30 | US Catanzaro 1929 | Padova Calcio | 0-1 |
| 24/10/25 19:45 | AC Milan | Pisa Sporting Club | 2-2 |
| 25/10/25 14:00 | Parma Calcio 1913 | Como Calcio | 0-0 |
| 25/10/25 14:00 | Udinese Calcio | US Lecce | 3-2 |
| 25/10/25 17:00 | SSC Napoli | Inter Milan | 3-1 |
| 25/10/25 19:45 | US Cremonese | Atalanta Bergamo | 1-1 |
| 26/10/25 11:30 | FC Turin | Genua CFC | 2-1 |
| 26/10/25 14:00 | Sassuolo Calcio | AS Roma | 0-1 |
| 26/10/25 14:00 | Hellas Verona | Cagliari Calcio | 2-2 |
| 26/10/25 17:00 | Fiorentina | FC Bologna | 2-2 |
| 26/10/25 19:45 | Lazio Rom | Juventus Turin | 1-0 |