| Date | Home | Away | Result |
|---|---|---|---|
| 24/10/25 19:30 | Modena FC | FC Empoli | 2-1 |
| 25/10/25 14:00 | Sampdoria Genua | Frosinone Calcio | 1-1 |
| 25/10/25 14:00 | FC Südtirol | FC Cesena | 0-1 |
| 25/10/25 14:00 | AC Monza | AC Reggiana 1919 | 3-1 |
| 25/10/25 14:00 | US Avellino | Spezia Calcio | 0-4 |
| 25/10/25 14:00 | Virtus Entella | Pescara Calcio | 1-1 |
| 25/10/25 16:15 | Carrarese Calcio 1908 | FC Venice | 3-2 |
| 25/10/25 18:30 | US Catanzaro 1929 | Palermo FC | 1-0 |
| 26/10/25 14:00 | Padova Calcio | Juve Stabia | 2-2 |
| 26/10/25 16:15 | SSC Bari | Mantova 1911 | 1-0 |
| 28/10/25 17:30 | US Lecce | SSC Napoli | --- |
| 28/10/25 19:45 | Atalanta Bergamo | AC Milan | --- |
| 29/10/25 17:30 | Como Calcio | Hellas Verona | --- |
| 29/10/25 17:30 | Juventus Turin | Udinese Calcio | --- |
| 29/10/25 17:30 | AS Roma | Parma Calcio 1913 | --- |
| 29/10/25 19:45 | FC Bologna | FC Turin | --- |
| 29/10/25 19:45 | Inter Milan | Fiorentina | --- |
| 29/10/25 19:45 | Genua CFC | US Cremonese | --- |
| 30/10/25 17:30 | Cagliari Calcio | Sassuolo Calcio | --- |
| 30/10/25 19:45 | Pisa Sporting Club | Lazio Rom | --- |