| Date | Home | Away | Result |
|---|---|---|---|
| 22/11/25 14:00 | US Avellino | FC Empoli | --- |
| 22/11/25 14:00 | SSC Bari | Frosinone Calcio | --- |
| 22/11/25 14:00 | Virtus Entella | Palermo FC | --- |
| 22/11/25 14:00 | Mantova 1911 | Spezia Calcio | --- |
| 22/11/25 14:00 | Carrarese Calcio 1908 | AC Reggiana 1919 | --- |
| 22/11/25 14:00 | US Catanzaro 1929 | Pescara Calcio | --- |
| 22/11/25 14:00 | Padova Calcio | FC Venice | --- |
| 22/11/25 14:00 | Sampdoria Genua | Juve Stabia | --- |
| 22/11/25 14:00 | Modena FC | FC Südtirol | --- |
| 22/11/25 14:00 | AC Monza | FC Cesena | --- |
| 30/11/25 17:00 | Genua CFC | Hellas Verona | --- |
| 30/11/25 17:00 | Como Calcio | Sassuolo Calcio | --- |
| 30/11/25 17:00 | US Lecce | FC Turin | --- |
| 30/11/25 17:00 | Juventus Turin | Cagliari Calcio | --- |
| 30/11/25 17:00 | Parma Calcio 1913 | Udinese Calcio | --- |
| 30/11/25 17:00 | AC Milan | Lazio Rom | --- |
| 30/11/25 17:00 | AS Roma | SSC Napoli | --- |
| 30/11/25 17:00 | Pisa Sporting Club | Inter Milan | --- |
| 30/11/25 17:00 | FC Bologna | US Cremonese | --- |
| 30/11/25 17:00 | Atalanta Bergamo | Fiorentina | --- |