| Date | Home | Away | Result |
|---|---|---|---|
| 09/08/25 19:30 | Virtus Entella | Ternana Calcio | 4-0 |
| 10/08/25 18:30 | Padova Calcio | Vicenza Calcio | 0-2 |
| 10/08/25 19:30 | US Avellino | Audace Cerignola | 0-1 |
| 10/08/25 19:30 | Pescara Calcio | Rimini FC | 1-0 |
| 15/08/25 17:00 | FC Empoli | AC Reggiana 1919 | 4-1a.PSO/1-1FT |
| 15/08/25 17:30 | Sassuolo Calcio | US Catanzaro 1929 | 1-0 |
| 15/08/25 19:45 | US Lecce | Juve Stabia | 2-0 |
| 15/08/25 20:15 | Genua CFC | Vicenza Calcio | 3-0 |
| 16/08/25 17:00 | FC Venice | Mantova 1911 | 4-0 |
| 16/08/25 17:30 | Como Calcio | FC Südtirol | 3-1 |
| 16/08/25 19:45 | Cagliari Calcio | Virtus Entella | 6-5a.PSO/1-1FT |
| 16/08/25 20:15 | US Cremonese | Palermo FC | 4-5a.PSO/0-0FT |
| 17/08/25 17:00 | AC Monza | Frosinone Calcio | 0-1 |
| 17/08/25 17:30 | Parma Calcio 1913 | Pescara Calcio | 2-0 |
| 17/08/25 19:45 | FC Cesena | Pisa Sporting Club | 1-2a.PSO/0-0FT |
| 17/08/25 20:15 | AC Milan | SSC Bari | 2-0 |
| 18/08/25 17:00 | Audace Cerignola | Hellas Verona | 3-5a.PSO/1-1FT |
| 18/08/25 17:30 | Spezia Calcio | Sampdoria Genua | 5-3a.PSO/1-1FT |
| 18/08/25 19:45 | Udinese Calcio | Carrarese Calcio 1908 | 2-0 |
| 18/08/25 20:15 | FC Turin | Modena FC | 1-0 |
| 22/08/25 19:30 | Pescara Calcio | FC Cesena | 1-3 |
| 23/08/25 17:30 | Genua CFC | US Lecce | 0-0 |
| 23/08/25 17:30 | Sassuolo Calcio | SSC Napoli | 0-2 |
| 23/08/25 18:00 | Virtus Entella | Juve Stabia | 1-1 |
| 23/08/25 18:00 | FC Empoli | Padova Calcio | 3-1 |
| 23/08/25 19:45 | AC Milan | US Cremonese | 1-2 |
| 23/08/25 19:45 | AS Roma | FC Bologna | 1-0 |
| 23/08/25 20:00 | AC Monza | Mantova 1911 | 1-0 |
| 23/08/25 20:00 | Palermo FC | AC Reggiana 1919 | 2-1 |
| 24/08/25 17:30 | Como Calcio | Lazio Rom | 2-0 |
| 24/08/25 17:30 | Cagliari Calcio | Fiorentina | 1-1 |
| 24/08/25 18:00 | Spezia Calcio | Carrarese Calcio 1908 | 0-2 |
| 24/08/25 18:00 | FC Venice | SSC Bari | 2-1 |
| 24/08/25 19:45 | Atalanta Bergamo | Pisa Sporting Club | 1-1 |
| 24/08/25 19:45 | Juventus Turin | Parma Calcio 1913 | 2-0 |
| 24/08/25 20:00 | Frosinone Calcio | US Avellino | 2-0 |
| 24/08/25 20:00 | US Catanzaro 1929 | FC Südtirol | 1-1 |
| 25/08/25 17:30 | Udinese Calcio | Hellas Verona | 1-1 |
| 25/08/25 19:30 | Sampdoria Genua | Modena FC | 0-2 |
| 25/08/25 19:45 | Inter Milan | FC Turin | 5-0 |