Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 02/09/22 17:30 | 02/09/22 17:30 | 1. FC Heidenheim 1846 | Fortuna Düsseldorf | 2-1 | 1 - 3 points |
| 02/09/22 17:30 | 02/09/22 17:30 | Eintracht Braunschweig | 1. FC Nürnberg | 4-2 | 1 - 3 points |
| 03/09/22 12:00 | 03/09/22 12:00 | SC Paderborn 07 | 1. FC Magdeburg | 1-0 | 1 - 3 points |
| 03/09/22 12:00 | 03/09/22 12:00 | Jahn Regensburg | Holstein Kiel | 0-0 | 1 - 3 points |
| 03/09/22 12:00 | 03/09/22 12:00 | SpVgg Greuther Fürth | FC St. Pauli | 2-2 | 1 - 3 points |
| 03/09/22 19:30 | 03/09/22 19:30 | Hamburger SV | Karlsruher SC | 1-0 | 1 - 3 points |
| 04/09/22 12:30 | 04/09/22 12:30 | SV Darmstadt 98 | Arminia Bielefeld | 1-1 | 1 - 3 points |
| 04/09/22 12:30 | 04/09/22 12:30 | FC Hansa Rostock | Hannover 96 | 0-1 | 1 - 3 points |
| 04/09/22 12:30 | 04/09/22 12:30 | SV Sandhausen | 1. FC Kaiserslautern | 0-0 | 1 - 3 points |