Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 27/08/21 17:30 | 27/08/21 17:30 | SV Sandhausen | FC Ingolstadt | 0-2 | 1 - 3 points |
| 27/08/21 17:30 | 27/08/21 17:30 | 1. FC Nürnberg | Karlsruher SC | 2-1 | 1 - 3 points |
| 28/08/21 12:30 | 28/08/21 12:30 | Holstein Kiel | Erzgebirge Aue | 3-0 | 1 - 3 points |
| 28/08/21 12:30 | 28/08/21 12:30 | SV Darmstadt 98 | Hannover 96 | 4-0 | 1 - 3 points |
| 28/08/21 12:30 | 28/08/21 12:30 | 1. FC Heidenheim 1846 | Hamburger SV | 0-0 | 1 - 3 points |
| 28/08/21 19:30 | 28/08/21 19:30 | FC Schalke 04 | Fortuna Düsseldorf | 3-1 | 1 - 3 points |
| 29/08/21 12:30 | 29/08/21 12:30 | Dynamo Dresden | SC Paderborn 07 | 0-3 | 1 - 3 points |
| 29/08/21 12:30 | 29/08/21 12:30 | Werder Bremen | FC Hansa Rostock | 3-0 | 1 - 3 points |
| 29/08/21 12:30 | 29/08/21 12:30 | FC St. Pauli | Jahn Regensburg | 2-0 | 1 - 3 points |