Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 16/04/22 12:30 | 16/04/22 12:30 | Hannover 96 | Fortuna Düsseldorf | 0-0 | 1 - 3 points |
| 16/04/22 12:30 | 16/04/22 12:30 | SV Sandhausen | FC St. Pauli | 1-1 | 1 - 3 points |
| 16/04/22 12:30 | 16/04/22 12:30 | Dynamo Dresden | Holstein Kiel | 0-0 | 1 - 3 points |
| 16/04/22 19:30 | 16/04/22 19:30 | Hamburger SV | Karlsruher SC | 3-0 | 1 - 3 points |
| 17/04/22 12:30 | 17/04/22 12:30 | FC Hansa Rostock | Jahn Regensburg | 1-1 | 1 - 3 points |
| 17/04/22 12:30 | 17/04/22 12:30 | FC Ingolstadt | SC Paderborn 07 | 0-1 | 1 - 3 points |
| 17/04/22 12:30 | 17/04/22 12:30 | Werder Bremen | 1. FC Nürnberg | 1-1 | 1 - 3 points |
| 17/04/22 12:30 | 17/04/22 12:30 | SV Darmstadt 98 | FC Schalke 04 | 2-5 | 1 - 3 points |
| 17/04/22 12:30 | 17/04/22 12:30 | 1. FC Heidenheim 1846 | Erzgebirge Aue | 0-2 | 1 - 3 points |