Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 08/04/22 17:30 | 08/04/22 17:30 | Jahn Regensburg | FC Ingolstadt | 1-1 | 1 - 3 points |
| 08/04/22 17:30 | 08/04/22 17:30 | Fortuna Düsseldorf | FC Hansa Rostock | 3-0 | 1 - 3 points |
| 09/04/22 12:30 | 09/04/22 12:30 | Erzgebirge Aue | Hannover 96 | 1-3 | 1 - 3 points |
| 09/04/22 12:30 | 09/04/22 12:30 | FC Schalke 04 | 1. FC Heidenheim 1846 | 3-0 | 1 - 3 points |
| 09/04/22 12:30 | 09/04/22 12:30 | FC St. Pauli | Werder Bremen | 1-1 | 1 - 3 points |
| 09/04/22 19:30 | 09/04/22 19:30 | 1. FC Nürnberg | SV Darmstadt 98 | 3-1 | 1 - 3 points |
| 10/04/22 12:30 | 10/04/22 12:30 | SV Sandhausen | Dynamo Dresden | 2-1 | 1 - 3 points |
| 10/04/22 12:30 | 10/04/22 12:30 | Holstein Kiel | Hamburger SV | 1-0 | 1 - 3 points |
| 10/04/22 12:30 | 10/04/22 12:30 | SC Paderborn 07 | Karlsruher SC | 2-2 | 1 - 3 points |