Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 07/10/22 17:30 | 07/10/22 17:30 | Arminia Bielefeld | Karlsruher SC | 1-2 | 1 - 3 points |
| 07/10/22 17:30 | 07/10/22 17:30 | Jahn Regensburg | SpVgg Greuther Fürth | 2-2 | 1 - 3 points |
| 08/10/22 12:00 | 08/10/22 12:00 | FC Hansa Rostock | SC Paderborn 07 | 0-3 | 1 - 3 points |
| 08/10/22 12:00 | 08/10/22 12:00 | SV Darmstadt 98 | Fortuna Düsseldorf | 1-0 | 1 - 3 points |
| 08/10/22 12:00 | 08/10/22 12:00 | Eintracht Braunschweig | FC St. Pauli | 2-1 | 1 - 3 points |
| 08/10/22 19:30 | 08/10/22 19:30 | Hamburger SV | 1. FC Kaiserslautern | 1-1 | 1 - 3 points |
| 09/10/22 12:30 | 09/10/22 12:30 | 1. FC Heidenheim 1846 | Hannover 96 | 2-1 | 1 - 3 points |
| 09/10/22 12:30 | 09/10/22 12:30 | 1. FC Nürnberg | Holstein Kiel | 2-3 | 1 - 3 points |
| 09/10/22 12:30 | 09/10/22 12:30 | SV Sandhausen | 1. FC Magdeburg | 1-0 | 1 - 3 points |