Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 28/09/21 17:45 | 28/09/21 17:45 | Schachtjor Donezk | Inter Milan | Group D | --- | 7 - 7 - 3 |
| 28/09/21 17:45 | 28/09/21 17:45 | Ajax Amsterdam | Besiktas Istanbul | Group C | --- | 3 - 7 - 7 |
| 28/09/21 20:00 | 28/09/21 20:00 | Real Madrid | Sheriff Tiraspol | Group D | --- | 3 - 7 - 7 |
| 28/09/21 20:00 | 28/09/21 20:00 | FC Porto | Liverpool FC | Group B | --- | 7 - 7 - 3 |
| 28/09/21 20:00 | 28/09/21 20:00 | AC Milan | Atletico Madrid | Group B | --- | 5 - 4 - 5 |
| 28/09/21 20:00 | 28/09/21 20:00 | RB Leipzig | Club Brugge | Group A | --- | 3 - 7 - 7 |
| 28/09/21 20:00 | 28/09/21 20:00 | Paris St. Germain | Manchester City | Group A | --- | 5 - 4 - 4 |
| 28/09/21 20:00 | 28/09/21 20:00 | Borussia Dortmund | Sporting Lisbon | Group C | --- | 3 - 7 - 7 |
| 29/09/21 17:45 | 29/09/21 17:45 | Zenit St. Petersburg | Malmö FF | Group H | --- | 3 - 6 - 7 |
| 29/09/21 17:45 | 29/09/21 17:45 | Atalanta Bergamo | Young Boys Bern | Group F | --- | 3 - 6 - 7 |
| 29/09/21 20:00 | 29/09/21 20:00 | Juventus Turin | Chelsea FC | Group H | --- | 7 - 5 - 3 |
| 29/09/21 20:00 | 29/09/21 20:00 | VfL Wolfsburg | FC Sevilla | Group G | --- | 4 - 5 - 5 |
| 29/09/21 20:00 | 29/09/21 20:00 | FC Red Bull Salzburg | OSC Lille | Group G | --- | 4 - 5 - 5 |
| 29/09/21 20:00 | 29/09/21 20:00 | Benfica Lisbon | FC Barcelona | Group E | --- | 7 - 6 - 3 |
| 29/09/21 20:00 | 29/09/21 20:00 | FC Bayern Munich | Dynamo Kiew | Group E | --- | 3 - 7 - 7 |
| 29/09/21 20:00 | 29/09/21 20:00 | Manchester United | FC Villarreal | Group F | --- | 3 - 7 - 7 |