Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| MLS | 23/04/22 20:00 | 23/04/22 20:00 | Philadelphia Union | CF Montreal | 1-1 | 3 - 5 - 5 |
| MLS | 23/04/22 20:00 | 23/04/22 20:00 | FC Dallas | Houston Dynamo | 2-1 | 3 - 5 - 5 |
| MLS | 23/04/22 22:00 | 23/04/22 22:00 | Minnesota United FC | Chicago Fire | 3-0 | 4 - 5 - 4 |
| MLS | 24/04/22 00:30 | 24/04/22 00:30 | D.C. United | New England Revolution | 3-2 | 3 - 5 - 4 |
| MLS | 24/04/22 01:30 | 24/04/22 01:30 | Austin FC | Vancouver Whitecaps | 3-0 | 3 - 5 - 5 |
| MLS | 24/04/22 01:30 | 24/04/22 01:30 | Sporting Kansas City | Columbus Crew | 0-0 | 3 - 5 - 5 |
| MLS | 24/04/22 02:00 | 24/04/22 02:00 | Colorado Rapids | Charlotte FC | 0-0 | 3 - 5 - 4 |
| MLS | 24/04/22 03:00 | 24/04/22 03:00 | Portland Timbers | Real Salt Lake | 0-0 | 3 - 5 - 5 |
| MLS | 24/04/22 03:00 | 24/04/22 03:00 | San Jose Earthquakes | Seattle Sounders | 4-3 | 5 - 5 - 3 |
| MLS | 24/04/22 03:30 | 24/04/22 03:30 | Los Angeles Galaxy | Nashville SC | 1-0 | 3 - 5 - 5 |
| MLS | 24/04/22 18:00 | 24/04/22 18:00 | Inter Miami CF | Atlanta United FC | 2-1 | 5 - 5 - 3 |
| MLS | 24/04/22 20:30 | 24/04/22 20:30 | Orlando City | New York Red Bulls | 0-3 | 4 - 5 - 4 |
| MLS | 24/04/22 22:00 | 24/04/22 22:00 | Cincinnati FC | Los Angeles FC | 1-2 | 5 - 5 - 3 |
| MLS | 24/04/22 22:00 | 24/04/22 22:00 | New York City FC | Toronto FC | 5-4 | 3 - 5 - 5 |