Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| MLS | 16/04/22 20:00 | 16/04/22 20:00 | CF Montreal | Vancouver Whitecaps | 2-1 | 3 - 5 - 5 |
| MLS | 16/04/22 20:30 | 16/04/22 20:30 | San Jose Earthquakes | Nashville SC | 2-2 | 4 - 5 - 3 |
| MLS | 16/04/22 23:00 | 16/04/22 23:00 | Houston Dynamo | Portland Timbers | 0-0 | 4 - 4 - 4 |
| MLS | 16/04/22 23:00 | 16/04/22 23:00 | Atlanta United FC | Cincinnati FC | 0-0 | 3 - 5 - 5 |
| MLS | 17/04/22 00:00 | 17/04/22 00:00 | New York Red Bulls | FC Dallas | 0-0 | 3 - 5 - 4 |
| MLS | 17/04/22 00:30 | 17/04/22 00:30 | Toronto FC | Philadelphia Union | 2-1 | 4 - 5 - 3 |
| MLS | 17/04/22 00:30 | 17/04/22 00:30 | D.C. United | Austin FC | 2-3 | 3 - 5 - 4 |
| MLS | 17/04/22 00:30 | 17/04/22 00:30 | Columbus Crew | Orlando City | 0-2 | 3 - 5 - 5 |
| MLS | 17/04/22 00:30 | 17/04/22 00:30 | New England Revolution | Charlotte FC | 2-1 | 3 - 5 - 4 |
| MLS | 17/04/22 01:00 | 17/04/22 01:00 | Minnesota United FC | Colorado Rapids | 3-1 | 4 - 4 - 5 |
| MLS | 17/04/22 01:00 | 17/04/22 01:00 | Chicago Fire | Los Angeles Galaxy | 0-0 | 5 - 5 - 3 |
| MLS | 17/04/22 03:00 | 17/04/22 03:00 | Seattle Sounders | Inter Miami CF | 0-1 | 3 - 5 - 5 |
| MLS | 17/04/22 18:00 | 17/04/22 18:00 | New York City FC | Real Salt Lake | 6-0 | 3 - 5 - 5 |
| MLS | 17/04/22 21:00 | 17/04/22 21:00 | Los Angeles FC | Sporting Kansas City | 3-1 | 3 - 5 - 5 |