Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| MLS | 28/05/22 23:00 | 28/05/22 23:00 | Los Angeles FC | San Jose Earthquakes | 3-2 | 3 - 5 - 5 |
| MLS | 29/05/22 00:00 | 29/05/22 00:00 | Atlanta United FC | Columbus Crew | 1-2 | 3 - 5 - 5 |
| MLS | 29/05/22 00:00 | 29/05/22 00:00 | Toronto FC | Chicago Fire | 3-2 | 3 - 5 - 5 |
| MLS | 29/05/22 00:00 | 29/05/22 00:00 | New York Red Bulls | D.C. United | 4-1 | 3 - 5 - 5 |
| MLS | 29/05/22 00:30 | 29/05/22 00:30 | Orlando City | FC Dallas | 1-3 | 3 - 5 - 4 |
| MLS | 29/05/22 00:30 | 29/05/22 00:30 | CF Montreal | Cincinnati FC | 4-3 | 3 - 5 - 4 |
| MLS | 29/05/22 00:30 | 29/05/22 00:30 | New England Revolution | Philadelphia Union | 1-1 | 3 - 5 - 4 |
| MLS | 29/05/22 01:00 | 29/05/22 01:00 | Minnesota United FC | New York City FC | 0-1 | 5 - 5 - 3 |
| MLS | 29/05/22 01:00 | 29/05/22 01:00 | Inter Miami CF | Portland Timbers | 2-1 | 3 - 5 - 5 |
| MLS | 29/05/22 02:00 | 29/05/22 02:00 | Colorado Rapids | Nashville SC | 1-3 | 4 - 4 - 4 |
| MLS | 29/05/22 02:00 | 29/05/22 02:00 | Sporting Kansas City | Vancouver Whitecaps | 0-1 | 3 - 5 - 5 |
| MLS | 29/05/22 02:30 | 29/05/22 02:30 | Real Salt Lake | Houston Dynamo | 3-0 | 3 - 5 - 5 |
| MLS | 29/05/22 23:00 | 29/05/22 23:00 | Los Angeles Galaxy | Austin FC | 4-1 | 3 - 5 - 5 |
| MLS | 30/05/22 02:30 | 30/05/22 02:30 | Seattle Sounders | Charlotte FC | 2-1 | 3 - 5 - 5 |