Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| MLS | 14/05/22 20:00 | 14/05/22 20:00 | Toronto FC | Orlando City | 0-1 | 4 - 5 - 4 |
| MLS | 14/05/22 20:30 | 14/05/22 20:30 | Colorado Rapids | Los Angeles FC | 2-0 | 5 - 5 - 3 |
| MLS | 15/05/22 00:00 | 15/05/22 00:00 | New York City FC | Columbus Crew | 2-0 | 3 - 5 - 5 |
| MLS | 15/05/22 00:00 | 15/05/22 00:00 | Charlotte FC | CF Montreal | 0-2 | 4 - 5 - 4 |
| MLS | 15/05/22 00:00 | 15/05/22 00:00 | Vancouver Whitecaps | San Jose Earthquakes | 3-3 | 3 - 5 - 5 |
| MLS | 15/05/22 00:30 | 15/05/22 00:30 | Philadelphia Union | New York Red Bulls | 1-1 | 3 - 5 - 4 |
| MLS | 15/05/22 01:00 | 15/05/22 01:00 | Inter Miami CF | D.C. United | 2-2 | 4 - 5 - 4 |
| MLS | 15/05/22 01:00 | 15/05/22 01:00 | Chicago Fire | Cincinnati FC | 1-2 | 3 - 5 - 4 |
| MLS | 15/05/22 01:30 | 15/05/22 01:30 | Houston Dynamo | Nashville SC | 2-0 | 3 - 5 - 5 |
| MLS | 15/05/22 02:30 | 15/05/22 02:30 | Real Salt Lake | Austin FC | 2-1 | 3 - 4 - 5 |
| MLS | 15/05/22 03:00 | 15/05/22 03:00 | Portland Timbers | Sporting Kansas City | 7-2 | 3 - 5 - 5 |
| MLS | 15/05/22 03:30 | 15/05/22 03:30 | Los Angeles Galaxy | FC Dallas | 1-3 | 3 - 5 - 5 |
| MLS | 15/05/22 18:55 | 15/05/22 18:55 | Atlanta United FC | New England Revolution | 2-2 | 3 - 5 - 5 |
| MLS | 15/05/22 21:00 | 15/05/22 21:00 | Seattle Sounders | Minnesota United FC | 3-1 | 3 - 5 - 5 |