Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 23/06/21 00:30 | 23/06/21 00:30 | Orlando City | San Jose Earthquakes | 5-0 | 3 - 5 - 5 |
| 24/06/21 00:00 | 24/06/21 00:00 | New England Revolution | New York Red Bulls | 3-2 | 3 - 4 - 5 |
| 24/06/21 00:30 | 24/06/21 00:30 | New York City FC | Atlanta United FC | 1-0 | 3 - 5 - 4 |
| 24/06/21 00:30 | 24/06/21 00:30 | Philadelphia Union | Columbus Crew | 1-0 | 3 - 5 - 4 |
| 24/06/21 01:00 | 24/06/21 01:00 | Minnesota United FC | Austin FC | 2-0 | 3 - 5 - 5 |
| 24/06/21 01:00 | 24/06/21 01:00 | Chicago Fire | Cincinnati FC | 0-1 | 3 - 5 - 5 |
| 24/06/21 01:00 | 24/06/21 01:00 | CF Montreal | D.C. United | 0-0 | 3 - 5 - 4 |
| 24/06/21 01:30 | 24/06/21 01:30 | Nashville SC | Toronto FC | 3-2 | 3 - 5 - 5 |
| 24/06/21 01:30 | 24/06/21 01:30 | Sporting Kansas City | Colorado Rapids | 3-1 | 3 - 5 - 5 |
| 24/06/21 01:30 | 24/06/21 01:30 | Houston Dynamo | Portland Timbers | 2-2 | 4 - 5 - 4 |
| 24/06/21 03:00 | 24/06/21 03:00 | Seattle Sounders | Real Salt Lake | 2-1 | 3 - 5 - 5 |
| 24/06/21 03:30 | 24/06/21 03:30 | Los Angeles FC | FC Dallas | 2-0 | 3 - 5 - 5 |
| 24/06/21 03:30 | 24/06/21 03:30 | Vancouver Whitecaps | Los Angeles Galaxy | 1-2 | 5 - 5 - 3 |