Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 19/06/21 01:00 | 19/06/21 01:00 | New York Red Bulls | Nashville SC | 2-0 | 3 - 5 - 5 |
| 19/06/21 03:00 | 19/06/21 03:00 | Real Salt Lake | Vancouver Whitecaps | 3-1 | 3 - 5 - 5 |
| 20/06/21 00:30 | 20/06/21 00:30 | New York City FC | New England Revolution | 2-3 | 3 - 5 - 5 |
| 20/06/21 00:30 | 20/06/21 00:30 | Columbus Crew | Chicago Fire | 2-0 | 3 - 5 - 5 |
| 20/06/21 00:30 | 20/06/21 00:30 | Cincinnati FC | Colorado Rapids | 0-2 | 5 - 5 - 3 |
| 20/06/21 00:30 | 20/06/21 00:30 | Toronto FC | Orlando City | 2-3 | 4 - 5 - 4 |
| 20/06/21 01:00 | 20/06/21 01:00 | D.C. United | Inter Miami CF | 1-0 | 3 - 5 - 4 |
| 20/06/21 01:30 | 20/06/21 01:30 | FC Dallas | Minnesota United FC | 1-1 | 3 - 5 - 4 |
| 20/06/21 02:00 | 20/06/21 02:00 | Los Angeles Galaxy | Seattle Sounders | 1-2 | 4 - 5 - 4 |
| 20/06/21 02:00 | 20/06/21 02:00 | Austin FC | San Jose Earthquakes | 0-0 | 3 - 5 - 4 |
| 20/06/21 03:30 | 20/06/21 03:30 | Portland Timbers | Sporting Kansas City | 2-1 | 4 - 5 - 4 |
| 20/06/21 04:00 | 20/06/21 04:00 | Los Angeles FC | Houston Dynamo | 1-1 | 3 - 5 - 4 |
| 20/06/21 19:00 | 20/06/21 19:00 | Atlanta United FC | Philadelphia Union | 2-2 | 3 - 5 - 4 |