Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 29/05/21 18:00 | 29/05/21 18:00 | Chicago Fire | CF Montreal | 0-1 | 3 - 5 - 4 |
| 29/05/21 18:00 | 29/05/21 18:00 | New York Red Bulls | Orlando City | 2-1 | 3 - 5 - 4 |
| 29/05/21 20:00 | 29/05/21 20:00 | Columbus Crew | Toronto FC | 2-1 | 3 - 5 - 5 |
| 29/05/21 20:00 | 29/05/21 20:00 | Cincinnati FC | New England Revolution | 0-1 | 5 - 5 - 3 |
| 29/05/21 20:30 | 29/05/21 20:30 | Atlanta United FC | Nashville SC | 2-2 | 3 - 5 - 5 |
| 29/05/21 22:00 | 29/05/21 22:00 | Los Angeles FC | New York City FC | 1-2 | 3 - 5 - 5 |
| 30/05/21 00:00 | 30/05/21 00:00 | Los Angeles Galaxy | San Jose Earthquakes | 1-0 | 3 - 5 - 5 |
| 30/05/21 01:00 | 30/05/21 01:00 | Inter Miami CF | D.C. United | 0-3 | 3 - 5 - 5 |
| 30/05/21 01:30 | 30/05/21 01:30 | Sporting Kansas City | Houston Dynamo | 3-2 | 3 - 5 - 5 |
| 30/05/21 02:00 | 30/05/21 02:00 | Colorado Rapids | FC Dallas | 3-0 | 3 - 5 - 5 |
| 30/05/21 02:30 | 30/05/21 02:30 | Real Salt Lake | Minnesota United FC | 1-1 | 3 - 5 - 5 |
| 31/05/21 00:00 | 31/05/21 00:00 | Philadelphia Union | Portland Timbers | 3-0 | 4 - 4 - 4 |
| 31/05/21 02:30 | 31/05/21 02:30 | Seattle Sounders | Austin FC | 0-0 | 3 - 5 - 5 |