Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 22/05/21 18:00 | 22/05/21 18:00 | CF Montreal | Cincinnati FC | 1-2 | 3 - 5 - 5 |
| 22/05/21 20:30 | 22/05/21 20:30 | Portland Timbers | Los Angeles Galaxy | 3-0 | 4 - 5 - 4 |
| 22/05/21 23:00 | 22/05/21 23:00 | Chicago Fire | Inter Miami CF | 1-0 | 4 - 5 - 3 |
| 23/05/21 00:00 | 23/05/21 00:00 | Orlando City | Toronto FC | 1-0 | 3 - 5 - 5 |
| 23/05/21 00:30 | 23/05/21 00:30 | New York City FC | Columbus Crew | 1-2 | 3 - 5 - 5 |
| 23/05/21 01:00 | 23/05/21 01:00 | New England Revolution | New York Red Bulls | 3-1 | 4 - 5 - 4 |
| 23/05/21 01:00 | 23/05/21 01:00 | FC Dallas | Real Salt Lake | 2-2 | 4 - 5 - 4 |
| 23/05/21 02:00 | 23/05/21 02:00 | Houston Dynamo | Vancouver Whitecaps | 2-1 | 3 - 5 - 5 |
| 23/05/21 03:00 | 23/05/21 03:00 | San Jose Earthquakes | Sporting Kansas City | 1-3 | 4 - 5 - 4 |
| 23/05/21 03:30 | 23/05/21 03:30 | Los Angeles FC | Colorado Rapids | 2-1 | 3 - 5 - 5 |
| 23/05/21 21:30 | 23/05/21 21:30 | Seattle Sounders | Atlanta United FC | 1-1 | 3 - 5 - 5 |
| 24/05/21 00:15 | 24/05/21 00:15 | D.C. United | Philadelphia Union | 0-1 | 4 - 5 - 4 |
| 24/05/21 02:00 | 24/05/21 02:00 | Nashville SC | Austin FC | 1-0 | 3 - 5 - 5 |