Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 09/05/21 20:00 | 09/05/21 20:00 | Portland Timbers | Seattle Sounders | 1-2 | 5 - 5 - 3 |
| 13/05/21 00:00 | 13/05/21 00:00 | Toronto FC | Columbus Crew | 2-0 | 4 - 5 - 3 |
| 13/05/21 00:30 | 13/05/21 00:30 | Inter Miami CF | CF Montreal | 0-2 | 3 - 5 - 5 |
| 13/05/21 00:30 | 13/05/21 00:30 | Philadelphia Union | New England Revolution | 1-1 | 4 - 5 - 4 |
| 13/05/21 01:30 | 13/05/21 01:30 | Houston Dynamo | Sporting Kansas City | 1-0 | 3 - 5 - 4 |
| 13/05/21 02:00 | 13/05/21 02:00 | Minnesota United FC | Vancouver Whitecaps | 1-0 | 3 - 5 - 4 |
| 13/05/21 03:30 | 13/05/21 03:30 | San Jose Earthquakes | Seattle Sounders | 0-1 | 4 - 5 - 3 |
| 14/05/21 01:00 | 14/05/21 01:00 | D.C. United | Chicago Fire | 1-0 | 3 - 5 - 5 |
| 15/05/21 18:00 | 15/05/21 18:00 | New York City FC | Toronto FC | 1-1 | 3 - 5 - 5 |
| 15/05/21 20:30 | 15/05/21 20:30 | Los Angeles Galaxy | Austin FC | 2-0 | 3 - 5 - 5 |
| 16/05/21 00:00 | 16/05/21 00:00 | Atlanta United FC | CF Montreal | 1-0 | 3 - 5 - 5 |
| 16/05/21 00:30 | 16/05/21 00:30 | Philadelphia Union | New York Red Bulls | 1-0 | 3 - 5 - 4 |
| 16/05/21 01:00 | 16/05/21 01:00 | Minnesota United FC | FC Dallas | 1-0 | 3 - 5 - 4 |
| 16/05/21 02:00 | 16/05/21 02:00 | Colorado Rapids | Houston Dynamo | 3-1 | 3 - 5 - 4 |
| 16/05/21 02:30 | 16/05/21 02:30 | Real Salt Lake | Nashville SC | 0-0 | 3 - 5 - 5 |
| 16/05/21 03:00 | 16/05/21 03:00 | San Jose Earthquakes | Portland Timbers | 0-2 | 4 - 5 - 4 |
| 16/05/21 19:00 | 16/05/21 19:00 | Sporting Kansas City | Vancouver Whitecaps | 3-0 | 3 - 5 - 5 |
| 16/05/21 21:00 | 16/05/21 21:00 | Cincinnati FC | Inter Miami CF | 2-3 | 5 - 5 - 3 |
| 16/05/21 23:00 | 16/05/21 23:00 | New England Revolution | Columbus Crew | 1-0 | 3 - 5 - 4 |
| 17/05/21 01:00 | 17/05/21 01:00 | D.C. United | Orlando City | 0-1 | 3 - 5 - 4 |
| 17/05/21 02:30 | 17/05/21 02:30 | Seattle Sounders | Los Angeles FC | 2-0 | 3 - 5 - 5 |