Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| MLS | 19/03/22 17:00 | 19/03/22 17:00 | New York City FC | Philadelphia Union | 0-2 | 3 - 5 - 5 |
| MLS | 19/03/22 17:00 | 19/03/22 17:00 | Cincinnati FC | Inter Miami CF | 3-1 | 4 - 5 - 4 |
| MLS | 19/03/22 19:00 | 19/03/22 19:00 | Toronto FC | D.C. United | 2-1 | 3 - 5 - 4 |
| MLS | 19/03/22 19:30 | 19/03/22 19:30 | Los Angeles Galaxy | Orlando City | 0-1 | 3 - 5 - 5 |
| MLS | 19/03/22 20:00 | 19/03/22 20:00 | Atlanta United FC | CF Montreal | 3-3 | 3 - 5 - 5 |
| MLS | 19/03/22 22:00 | 19/03/22 22:00 | Chicago Fire | Sporting Kansas City | 3-1 | 3 - 5 - 5 |
| MLS | 19/03/22 23:00 | 19/03/22 23:00 | Charlotte FC | New England Revolution | 3-1 | 5 - 5 - 3 |
| MLS | 20/03/22 00:00 | 20/03/22 00:00 | Minnesota United FC | San Jose Earthquakes | 1-0 | 3 - 5 - 5 |
| MLS | 20/03/22 00:30 | 20/03/22 00:30 | FC Dallas | Portland Timbers | 4-1 | 4 - 5 - 3 |
| MLS | 20/03/22 00:30 | 20/03/22 00:30 | Houston Dynamo | Colorado Rapids | 1-1 | 5 - 5 - 3 |
| MLS | 20/03/22 01:30 | 20/03/22 01:30 | Real Salt Lake | Nashville SC | 2-1 | 3 - 5 - 5 |
| MLS | 20/03/22 18:00 | 20/03/22 18:00 | New York Red Bulls | Columbus Crew | 1-1 | 3 - 5 - 5 |
| MLS | 20/03/22 20:30 | 20/03/22 20:30 | Austin FC | Seattle Sounders | 1-1 | 5 - 5 - 3 |
| MLS | 21/03/22 02:00 | 21/03/22 02:00 | Los Angeles FC | Vancouver Whitecaps | 3-1 | 3 - 5 - 5 |