Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 08/05/21 02:30 | 08/05/21 02:30 | Real Salt Lake | San Jose Earthquakes | 1-2 | 3 - 5 - 5 |
| 08/05/21 18:00 | 08/05/21 18:00 | New York Red Bulls | Toronto FC | 2-0 | 3 - 5 - 5 |
| 08/05/21 18:00 | 08/05/21 18:00 | Chicago Fire | Philadelphia Union | 0-2 | 4 - 5 - 4 |
| 08/05/21 18:30 | 08/05/21 18:30 | Columbus Crew | D.C. United | 3-1 | 3 - 5 - 5 |
| 08/05/21 18:30 | 08/05/21 18:30 | Nashville SC | New England Revolution | 2-0 | 4 - 5 - 4 |
| 08/05/21 20:00 | 08/05/21 20:00 | Vancouver Whitecaps | CF Montreal | 2-0 | 4 - 5 - 3 |
| 08/05/21 20:30 | 08/05/21 20:30 | FC Dallas | Houston Dynamo | 1-1 | 3 - 5 - 5 |
| 08/05/21 23:00 | 08/05/21 23:00 | Orlando City | New York City FC | 1-1 | 4 - 5 - 4 |
| 09/05/21 01:00 | 09/05/21 01:00 | Los Angeles Galaxy | Los Angeles FC | 2-1 | 3 - 5 - 4 |
| 09/05/21 03:00 | 09/05/21 03:00 | Colorado Rapids | Minnesota United FC | 3-2 | 3 - 5 - 5 |
| 09/05/21 18:00 | 09/05/21 18:00 | Inter Miami CF | Atlanta United FC | 1-1 | 3 - 5 - 4 |
| 10/05/21 00:30 | 10/05/21 00:30 | Sporting Kansas City | Austin FC | 2-1 | 3 - 5 - 5 |