Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 20/11/21 19:30 | 20/11/21 19:30 | Philadelphia Union | New York Red Bulls | 1-0a.e.t | 3 - 5 - 4 |
| 20/11/21 22:00 | 20/11/21 22:00 | Sporting Kansas City | Vancouver Whitecaps | 3-1 | 3 - 5 - 5 |
| 21/11/21 20:00 | 21/11/21 20:00 | New York City FC | Atlanta United FC | 2-0 | 3 - 5 - 5 |
| 21/11/21 22:30 | 21/11/21 22:30 | Portland Timbers | Minnesota United FC | 3-1 | 3 - 5 - 4 |
| 24/11/21 01:00 | 24/11/21 01:00 | Nashville SC | Orlando City | 3-1 | 3 - 5 - 5 |
| 24/11/21 03:30 | 24/11/21 03:30 | Seattle Sounders | Real Salt Lake | 5-6a.PSO | 3 - 5 - 5 |