Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 16/10/21 18:00 | 16/10/21 18:00 | CF Montreal | Philadelphia Union | 2-2 | 3 - 5 - 4 |
| 16/10/21 20:30 | 16/10/21 20:30 | Los Angeles FC | San Jose Earthquakes | 3-1 | 3 - 5 - 5 |
| 16/10/21 23:00 | 16/10/21 23:00 | Columbus Crew | Inter Miami CF | 4-0 | 3 - 5 - 5 |
| 17/10/21 00:00 | 17/10/21 00:00 | New England Revolution | Chicago Fire | 2-2 | 3 - 5 - 5 |
| 17/10/21 00:30 | 17/10/21 00:30 | D.C. United | Nashville SC | 0-0 | 3 - 5 - 5 |
| 17/10/21 00:30 | 17/10/21 00:30 | Cincinnati FC | Orlando City | 0-1 | 5 - 5 - 3 |
| 17/10/21 00:30 | 17/10/21 00:30 | Toronto FC | Atlanta United FC | 0-2 | 3 - 5 - 4 |
| 17/10/21 01:30 | 17/10/21 01:30 | Houston Dynamo | Seattle Sounders | 2-1 | 5 - 5 - 3 |
| 17/10/21 02:00 | 17/10/21 02:00 | Austin FC | Minnesota United FC | 0-1 | 4 - 5 - 4 |
| 17/10/21 02:30 | 17/10/21 02:30 | Real Salt Lake | Colorado Rapids | 3-1 | 3 - 5 - 4 |
| 17/10/21 03:30 | 17/10/21 03:30 | Los Angeles Galaxy | Portland Timbers | 2-1 | 4 - 5 - 4 |
| 17/10/21 18:00 | 17/10/21 18:00 | New York Red Bulls | New York City FC | 1-0 | 3 - 5 - 4 |
| 18/10/21 03:00 | 18/10/21 03:00 | Vancouver Whitecaps | Sporting Kansas City | 2-1 | 4 - 5 - 4 |