Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 27/10/21 03:30 | 27/10/21 03:30 | Los Angeles FC | Seattle Sounders | 3-0 | 3 - 5 - 4 |
| 28/10/21 00:00 | 28/10/21 00:00 | New England Revolution | Colorado Rapids | 1-0 | 3 - 5 - 5 |
| 28/10/21 00:30 | 28/10/21 00:30 | Toronto FC | Philadelphia Union | 2-2 | 4 - 5 - 4 |
| 28/10/21 00:30 | 28/10/21 00:30 | Columbus Crew | Orlando City | 3-2 | 3 - 5 - 5 |
| 28/10/21 00:30 | 28/10/21 00:30 | Cincinnati FC | Nashville SC | 3-6 | 4 - 5 - 3 |
| 28/10/21 00:30 | 28/10/21 00:30 | Atlanta United FC | Inter Miami CF | 2-1 | 3 - 5 - 5 |
| 28/10/21 00:30 | 28/10/21 00:30 | D.C. United | New York Red Bulls | 1-0 | 4 - 5 - 4 |
| 28/10/21 00:30 | 28/10/21 00:30 | New York City FC | Chicago Fire | 1-0 | 3 - 5 - 5 |
| 28/10/21 01:00 | 28/10/21 01:00 | FC Dallas | Real Salt Lake | 1-2 | 3 - 5 - 4 |
| 28/10/21 01:30 | 28/10/21 01:30 | Sporting Kansas City | Los Angeles Galaxy | 2-0 | 3 - 5 - 4 |
| 28/10/21 03:00 | 28/10/21 03:00 | Portland Timbers | San Jose Earthquakes | 2-0 | 3 - 5 - 5 |
| 28/10/21 03:00 | 28/10/21 03:00 | Vancouver Whitecaps | Minnesota United FC | 2-1 | 4 - 5 - 4 |