Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 23/10/21 20:30 | 23/10/21 20:30 | Seattle Sounders | Sporting Kansas City | 1-2 | 3 - 5 - 5 |
| 23/10/21 23:00 | 23/10/21 23:00 | Columbus Crew | New York Red Bulls | 1-2 | 3 - 5 - 5 |
| 24/10/21 00:30 | 24/10/21 00:30 | Toronto FC | CF Montreal | 1-1 | 3 - 5 - 4 |
| 24/10/21 00:30 | 24/10/21 00:30 | Philadelphia Union | Nashville SC | 1-0 | 3 - 5 - 5 |
| 24/10/21 00:30 | 24/10/21 00:30 | New York City FC | D.C. United | 6-0 | 3 - 5 - 5 |
| 24/10/21 01:00 | 24/10/21 01:00 | Inter Miami CF | Cincinnati FC | 5-1 | 3 - 5 - 5 |
| 24/10/21 01:00 | 24/10/21 01:00 | Chicago Fire | Real Salt Lake | 1-0 | 4 - 5 - 3 |
| 24/10/21 01:00 | 24/10/21 01:00 | Minnesota United FC | Los Angeles FC | 1-1 | 3 - 5 - 4 |
| 24/10/21 02:00 | 24/10/21 02:00 | Colorado Rapids | Portland Timbers | 2-0 | 3 - 5 - 5 |
| 24/10/21 03:00 | 24/10/21 03:00 | San Jose Earthquakes | Vancouver Whitecaps | 1-1 | 3 - 5 - 4 |
| 24/10/21 03:00 | 24/10/21 03:00 | Los Angeles Galaxy | FC Dallas | 2-2 | 3 - 5 - 5 |
| 24/10/21 22:00 | 24/10/21 22:00 | Austin FC | Houston Dynamo | 2-1 | 3 - 5 - 4 |
| 25/10/21 00:30 | 25/10/21 00:30 | Orlando City | New England Revolution | 2-2 | 4 - 5 - 3 |