Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 01/05/21 18:00 | 01/05/21 18:00 | New York Red Bulls | Chicago Fire | 2-0 | 3 - 5 - 5 |
| 01/05/21 19:00 | 01/05/21 19:00 | Real Salt Lake | Sporting Kansas City | 3-1 | 4 - 5 - 3 |
| 01/05/21 20:00 | 01/05/21 20:00 | CF Montreal | Columbus Crew | 0-0 | 3 - 5 - 4 |
| 01/05/21 20:30 | 01/05/21 20:30 | Houston Dynamo | Los Angeles FC | 1-1 | 5 - 5 - 3 |
| 02/05/21 00:00 | 02/05/21 00:00 | New England Revolution | Atlanta United FC | 2-1 | 4 - 5 - 4 |
| 02/05/21 00:30 | 02/05/21 00:30 | Orlando City | Cincinnati FC | 3-0 | 3 - 5 - 5 |
| 02/05/21 00:30 | 02/05/21 00:30 | Philadelphia Union | New York City FC | 0-2 | 4 - 5 - 4 |
| 02/05/21 01:00 | 02/05/21 01:00 | Minnesota United FC | Austin FC | 0-1 | 3 - 5 - 5 |
| 02/05/21 01:00 | 02/05/21 01:00 | FC Dallas | Portland Timbers | 4-1 | 4 - 5 - 4 |
| 02/05/21 04:00 | 02/05/21 04:00 | San Jose Earthquakes | D.C. United | 4-1 | 3 - 5 - 5 |
| 02/05/21 18:00 | 02/05/21 18:00 | Nashville SC | Inter Miami CF | 0-0 | 5 - 5 - 3 |
| 03/05/21 02:00 | 03/05/21 02:00 | Seattle Sounders | Los Angeles Galaxy | 3-0 | 4 - 5 - 4 |
| 03/05/21 03:00 | 03/05/21 03:00 | Vancouver Whitecaps | Colorado Rapids | 0-1 | 3 - 5 - 5 |