Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 02/10/21 20:30 | 02/10/21 20:30 | Austin FC | Real Salt Lake | 2-1 | 3 - 5 - 4 |
| 03/10/21 00:00 | 03/10/21 00:00 | CF Montreal | Atlanta United FC | 2-1 | 4 - 5 - 4 |
| 03/10/21 00:30 | 03/10/21 00:30 | Orlando City | D.C. United | 2-1 | 3 - 5 - 5 |
| 03/10/21 00:30 | 03/10/21 00:30 | Cincinnati FC | New York Red Bulls | 0-1 | 5 - 5 - 3 |
| 03/10/21 01:00 | 03/10/21 01:00 | FC Dallas | Minnesota United FC | 0-0 | 3 - 5 - 4 |
| 03/10/21 03:00 | 03/10/21 03:00 | Vancouver Whitecaps | San Jose Earthquakes | 3-0 | 3 - 5 - 5 |
| 03/10/21 17:00 | 03/10/21 17:00 | New York City FC | Nashville SC | 0-0 | 3 - 5 - 5 |
| 03/10/21 21:00 | 03/10/21 21:00 | Philadelphia Union | Columbus Crew | 3-0 | 3 - 5 - 5 |
| 03/10/21 21:00 | 03/10/21 21:00 | Sporting Kansas City | Houston Dynamo | 4-2 | 3 - 5 - 5 |
| 03/10/21 21:00 | 03/10/21 21:00 | Toronto FC | Chicago Fire | 3-1 | 3 - 5 - 5 |
| 03/10/21 22:30 | 03/10/21 22:30 | Portland Timbers | Inter Miami CF | 1-0 | 3 - 5 - 5 |
| 04/10/21 01:00 | 04/10/21 01:00 | Los Angeles Galaxy | Los Angeles FC | 1-1 | 3 - 5 - 5 |
| 04/10/21 03:00 | 04/10/21 03:00 | Seattle Sounders | Colorado Rapids | 3-0 | 3 - 5 - 5 |