Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 30/09/21 00:00 | 30/09/21 00:00 | Atlanta United FC | Inter Miami CF | 1-0 | 3 - 5 - 5 |
| 30/09/21 00:00 | 30/09/21 00:00 | Toronto FC | Cincinnati FC | 3-2 | 3 - 5 - 5 |
| 30/09/21 00:30 | 30/09/21 00:30 | New York Red Bulls | Philadelphia Union | 1-1 | 3 - 5 - 4 |
| 30/09/21 00:30 | 30/09/21 00:30 | D.C. United | Minnesota United FC | 3-1 | 3 - 5 - 5 |
| 30/09/21 00:30 | 30/09/21 00:30 | CF Montreal | New England Revolution | 1-4 | 4 - 5 - 3 |
| 30/09/21 01:00 | 30/09/21 01:00 | Chicago Fire | New York City FC | 2-0 | 5 - 5 - 3 |
| 30/09/21 01:00 | 30/09/21 01:00 | FC Dallas | Sporting Kansas City | 1-3 | 3 - 5 - 4 |
| 30/09/21 01:30 | 30/09/21 01:30 | Nashville SC | Orlando City | 2-2 | 3 - 5 - 5 |
| 30/09/21 02:00 | 30/09/21 02:00 | Colorado Rapids | Austin FC | 3-0 | 3 - 5 - 5 |
| 30/09/21 02:00 | 30/09/21 02:00 | Houston Dynamo | Vancouver Whitecaps | 0-0 | 4 - 5 - 4 |
| 30/09/21 02:30 | 30/09/21 02:30 | Real Salt Lake | Los Angeles Galaxy | 2-1 | 4 - 5 - 3 |
| 30/09/21 03:30 | 30/09/21 03:30 | San Jose Earthquakes | Seattle Sounders | 1-3 | 4 - 5 - 3 |
| 30/09/21 03:30 | 30/09/21 03:30 | Los Angeles FC | Portland Timbers | 1-2 | 3 - 5 - 4 |