Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 23/09/21 00:30 | 23/09/21 00:30 | Inter Miami CF | Nashville SC | 1-5 | 4 - 5 - 4 |
| 25/09/21 20:30 | 25/09/21 20:30 | Philadelphia Union | Atlanta United FC | 1-0 | 4 - 5 - 4 |
| 26/09/21 00:00 | 26/09/21 00:00 | New England Revolution | Orlando City | 2-1 | 3 - 5 - 5 |
| 26/09/21 00:30 | 26/09/21 00:30 | D.C. United | Cincinnati FC | 4-2 | 3 - 5 - 5 |
| 26/09/21 00:30 | 26/09/21 00:30 | Columbus Crew | CF Montreal | 2-1 | 3 - 5 - 4 |
| 26/09/21 01:00 | 26/09/21 01:00 | New York City FC | New York Red Bulls | 0-1 | 3 - 5 - 4 |
| 26/09/21 01:00 | 26/09/21 01:00 | Minnesota United FC | Houston Dynamo | 2-0 | 3 - 5 - 5 |
| 26/09/21 01:00 | 26/09/21 01:00 | Colorado Rapids | Toronto FC | 0-0 | 3 - 5 - 5 |
| 26/09/21 03:00 | 26/09/21 03:00 | San Jose Earthquakes | Los Angeles FC | 2-0 | 4 - 5 - 3 |
| 26/09/21 03:00 | 26/09/21 03:00 | Vancouver Whitecaps | FC Dallas | 1-0 | 3 - 5 - 5 |
| 26/09/21 03:30 | 26/09/21 03:30 | Portland Timbers | Real Salt Lake | 6-1 | 3 - 5 - 5 |
| 26/09/21 18:00 | 26/09/21 18:00 | Chicago Fire | Nashville SC | 0-0 | 4 - 5 - 4 |
| 27/09/21 00:00 | 27/09/21 00:00 | Sporting Kansas City | Seattle Sounders | 1-2 | 3 - 5 - 4 |
| 27/09/21 02:30 | 27/09/21 02:30 | Austin FC | Los Angeles Galaxy | 2-0 | 4 - 5 - 3 |