Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 18/09/21 00:00 | 18/09/21 00:00 | Inter Miami CF | New York Red Bulls | 0-4 | 3 - 5 - 4 |
| 18/09/21 20:30 | 18/09/21 20:30 | Atlanta United FC | D.C. United | 3-2 | 3 - 5 - 5 |
| 19/09/21 00:00 | 19/09/21 00:00 | New England Revolution | Columbus Crew | 1-1 | 3 - 5 - 5 |
| 19/09/21 00:30 | 19/09/21 00:30 | Cincinnati FC | New York City FC | 1-2 | 5 - 5 - 3 |
| 19/09/21 00:30 | 19/09/21 00:30 | Toronto FC | Nashville SC | 2-1 | 4 - 4 - 4 |
| 19/09/21 01:00 | 19/09/21 01:00 | Minnesota United FC | Los Angeles Galaxy | 3-0 | 4 - 5 - 4 |
| 19/09/21 01:00 | 19/09/21 01:00 | Austin FC | San Jose Earthquakes | 3-4 | 4 - 5 - 4 |
| 19/09/21 02:30 | 19/09/21 02:30 | Houston Dynamo | FC Dallas | 3-2 | 3 - 5 - 5 |
| 19/09/21 02:30 | 19/09/21 02:30 | Real Salt Lake | Seattle Sounders | 1-0 | 4 - 5 - 3 |
| 19/09/21 18:00 | 19/09/21 18:00 | CF Montreal | Chicago Fire | 2-0 | 3 - 5 - 5 |
| 19/09/21 21:00 | 19/09/21 21:00 | Philadelphia Union | Orlando City | 3-1 | 3 - 5 - 5 |
| 20/09/21 00:30 | 20/09/21 00:30 | Portland Timbers | Los Angeles FC | 2-1 | 4 - 5 - 4 |
| 20/09/21 02:00 | 20/09/21 02:00 | Colorado Rapids | Vancouver Whitecaps | 1-1 | 3 - 5 - 5 |