Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/09/21 00:00 | 11/09/21 00:00 | Atlanta United FC | Orlando City | 3-0 | 3 - 5 - 5 |
| 11/09/21 03:00 | 11/09/21 03:00 | Vancouver Whitecaps | Portland Timbers | 0-1 | 3 - 5 - 5 |
| 11/09/21 20:30 | 11/09/21 20:30 | Colorado Rapids | Los Angeles Galaxy | 1-1 | 3 - 5 - 4 |
| 11/09/21 22:00 | 11/09/21 22:00 | Seattle Sounders | Minnesota United FC | 1-0 | 3 - 5 - 5 |
| 12/09/21 00:00 | 12/09/21 00:00 | New York Red Bulls | D.C. United | 1-1 | 3 - 5 - 4 |
| 12/09/21 00:00 | 12/09/21 00:00 | New England Revolution | New York City FC | 2-1 | 3 - 5 - 5 |
| 12/09/21 01:00 | 12/09/21 01:00 | Cincinnati FC | Toronto FC | 2-0 | 4 - 5 - 4 |
| 12/09/21 01:00 | 12/09/21 01:00 | CF Montreal | Nashville SC | 0-1 | 4 - 5 - 4 |
| 12/09/21 01:00 | 12/09/21 01:00 | Inter Miami CF | Columbus Crew | 1-0 | 3 - 5 - 4 |
| 12/09/21 01:30 | 12/09/21 01:30 | Sporting Kansas City | Chicago Fire | 2-0 | 3 - 5 - 5 |
| 12/09/21 01:30 | 12/09/21 01:30 | Houston Dynamo | Austin FC | 3-0 | 4 - 5 - 4 |
| 12/09/21 01:30 | 12/09/21 01:30 | FC Dallas | San Jose Earthquakes | 1-1 | 3 - 5 - 4 |
| 13/09/21 03:30 | 13/09/21 03:30 | Los Angeles FC | Real Salt Lake | 3-2 | 3 - 5 - 5 |