Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 04/09/21 00:30 | 04/09/21 00:30 | Nashville SC | New York City FC | 3-1 | 3 - 5 - 5 |
| 04/09/21 01:00 | 04/09/21 01:00 | Houston Dynamo | Portland Timbers | 0-2 | 4 - 5 - 4 |
| 04/09/21 03:00 | 04/09/21 03:00 | Los Angeles FC | Sporting Kansas City | 4-0 | 4 - 5 - 4 |
| 05/09/21 00:30 | 05/09/21 00:30 | Orlando City | Columbus Crew | 3-2 | 3 - 5 - 5 |
| 05/09/21 01:00 | 05/09/21 01:00 | Cincinnati FC | Inter Miami CF | 0-1 | 3 - 5 - 5 |
| 05/09/21 01:00 | 05/09/21 01:00 | Real Salt Lake | FC Dallas | 3-2 | 3 - 5 - 5 |
| 05/09/21 03:00 | 05/09/21 03:00 | San Jose Earthquakes | Colorado Rapids | 0-1 | 4 - 5 - 4 |