Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 27/08/21 23:30 | 27/08/21 23:30 | Columbus Crew | Cincinnati FC | 3-2 | 3 - 5 - 5 |
| 28/08/21 00:30 | 28/08/21 00:30 | CF Montreal | Toronto FC | 3-1 | 3 - 5 - 5 |
| 28/08/21 01:30 | 28/08/21 01:30 | Orlando City | Inter Miami CF | 0-0 | 3 - 5 - 5 |
| 28/08/21 20:30 | 28/08/21 20:30 | Atlanta United FC | Nashville SC | 0-2 | 3 - 5 - 5 |
| 28/08/21 23:00 | 28/08/21 23:00 | New York Red Bulls | Chicago Fire | 0-1 | 3 - 5 - 5 |
| 29/08/21 00:00 | 29/08/21 00:00 | Los Angeles FC | Los Angeles Galaxy | 3-3 | 3 - 5 - 4 |
| 29/08/21 00:30 | 29/08/21 00:30 | New York City FC | New England Revolution | 2-0 | 4 - 5 - 4 |
| 29/08/21 01:00 | 29/08/21 01:00 | D.C. United | Philadelphia Union | 3-1 | 5 - 5 - 3 |
| 29/08/21 02:00 | 29/08/21 02:00 | Houston Dynamo | Minnesota United FC | 1-2 | 4 - 5 - 4 |
| 29/08/21 02:00 | 29/08/21 02:00 | Sporting Kansas City | Colorado Rapids | 1-1 | 3 - 5 - 5 |
| 30/08/21 01:00 | 30/08/21 01:00 | Austin FC | FC Dallas | 3-5 | 4 - 5 - 4 |
| 30/08/21 03:00 | 30/08/21 03:00 | Vancouver Whitecaps | Real Salt Lake | 4-1 | 4 - 5 - 4 |
| 30/08/21 03:30 | 30/08/21 03:30 | Seattle Sounders | Portland Timbers | 0-2 | 3 - 5 - 5 |