Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 18/08/21 03:30 | 18/08/21 03:30 | San Jose Earthquakes | Minnesota United FC | 1-1 | 3 - 5 - 4 |
| 18/08/21 03:30 | 18/08/21 03:30 | Los Angeles Galaxy | Colorado Rapids | 1-2 | 3 - 5 - 5 |
| 19/08/21 00:00 | 19/08/21 00:00 | New England Revolution | D.C. United | 3-2 | 3 - 5 - 5 |
| 19/08/21 00:00 | 19/08/21 00:00 | Atlanta United FC | Toronto FC | 1-0 | 3 - 5 - 5 |
| 19/08/21 00:30 | 19/08/21 00:30 | Inter Miami CF | Chicago Fire | 3-2 | 3 - 5 - 4 |
| 19/08/21 00:30 | 19/08/21 00:30 | Philadelphia Union | New York City FC | 1-0 | 4 - 5 - 4 |
| 19/08/21 00:30 | 19/08/21 00:30 | Cincinnati FC | CF Montreal | 0-0 | 3 - 5 - 4 |
| 19/08/21 01:00 | 19/08/21 01:00 | New York Red Bulls | Columbus Crew | 1-0 | 3 - 5 - 5 |
| 19/08/21 01:30 | 19/08/21 01:30 | Sporting Kansas City | Portland Timbers | 1-1 | 3 - 5 - 5 |
| 19/08/21 01:30 | 19/08/21 01:30 | Nashville SC | Orlando City | 1-1 | 3 - 4 - 5 |
| 19/08/21 01:30 | 19/08/21 01:30 | FC Dallas | Seattle Sounders | 0-1 | 5 - 5 - 3 |
| 19/08/21 02:00 | 19/08/21 02:00 | Austin FC | Vancouver Whitecaps | 1-2 | 3 - 5 - 4 |
| 19/08/21 03:00 | 19/08/21 03:00 | Real Salt Lake | Houston Dynamo | 2-1 | 3 - 5 - 5 |