Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 24/04/21 00:30 | 24/04/21 00:30 | Sporting Kansas City | Orlando City | 1-1 | 3 - 5 - 5 |
| 24/04/21 18:00 | 24/04/21 18:00 | New York City FC | Cincinnati FC | 5-0 | 3 - 5 - 5 |
| 24/04/21 19:00 | 24/04/21 19:00 | Nashville SC | CF Montreal | 2-2 | 4 - 5 - 3 |
| 24/04/21 20:00 | 24/04/21 20:00 | Toronto FC | Vancouver Whitecaps | 2-2 | 3 - 5 - 5 |
| 24/04/21 20:30 | 24/04/21 20:30 | San Jose Earthquakes | FC Dallas | 3-1 | 4 - 5 - 4 |
| 24/04/21 23:00 | 24/04/21 23:00 | Los Angeles FC | Seattle Sounders | 1-1 | 3 - 5 - 5 |
| 25/04/21 01:00 | 25/04/21 01:00 | New England Revolution | D.C. United | 1-0 | 3 - 5 - 4 |
| 25/04/21 01:00 | 25/04/21 01:00 | Philadelphia Union | Inter Miami CF | 1-2 | 3 - 5 - 5 |
| 25/04/21 01:00 | 25/04/21 01:00 | Atlanta United FC | Chicago Fire | 3-1 | 3 - 5 - 5 |
| 25/04/21 01:00 | 25/04/21 01:00 | Minnesota United FC | Real Salt Lake | 1-2 | 3 - 5 - 5 |
| 25/04/21 02:00 | 25/04/21 02:00 | Colorado Rapids | Austin FC | 1-3 | 3 - 5 - 5 |
| 25/04/21 03:30 | 25/04/21 03:30 | Portland Timbers | Houston Dynamo | 2-1 | 3 - 5 - 5 |
| 25/04/21 22:30 | 25/04/21 22:30 | Los Angeles Galaxy | New York Red Bulls | 3-2 | 3 - 5 - 5 |