Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 14/08/21 03:30 | 14/08/21 03:30 | San Jose Earthquakes | Vancouver Whitecaps | 0-0 | 3 - 5 - 5 |
| 14/08/21 23:00 | 14/08/21 23:00 | Minnesota United FC | Los Angeles Galaxy | 0-1 | 4 - 5 - 4 |
| 15/08/21 01:00 | 15/08/21 01:00 | Toronto FC | New England Revolution | 1-2 | 4 - 5 - 3 |
| 15/08/21 01:00 | 15/08/21 01:00 | CF Montreal | New York Red Bulls | 2-1 | 4 - 5 - 4 |
| 15/08/21 01:00 | 15/08/21 01:00 | New York City FC | Inter Miami CF | 2-0 | 3 - 5 - 5 |
| 15/08/21 01:30 | 15/08/21 01:30 | Houston Dynamo | Colorado Rapids | 1-3 | 4 - 4 - 4 |
| 15/08/21 01:30 | 15/08/21 01:30 | FC Dallas | Sporting Kansas City | 0-2 | 4 - 5 - 4 |
| 15/08/21 03:00 | 15/08/21 03:00 | Real Salt Lake | Austin FC | 1-0 | 3 - 5 - 5 |
| 15/08/21 21:00 | 15/08/21 21:00 | Atlanta United FC | Los Angeles FC | 1-0 | 4 - 5 - 4 |
| 15/08/21 23:00 | 15/08/21 23:00 | Chicago Fire | Columbus Crew | 1-0 | 3 - 5 - 4 |
| 16/08/21 00:00 | 16/08/21 00:00 | Nashville SC | D.C. United | 5-2 | 3 - 5 - 5 |
| 16/08/21 03:00 | 16/08/21 03:00 | Portland Timbers | Seattle Sounders | 2-6 | 4 - 5 - 4 |
| 10/10/21 01:00 | 10/10/21 01:00 | Cincinnati FC | Philadelphia Union | 1-2 | 5 - 5 - 3 |