Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 08/08/21 00:30 | 08/08/21 00:30 | Cincinnati FC | Orlando City | 1-1 | 5 - 5 - 3 |
| 08/08/21 00:30 | 08/08/21 00:30 | Columbus Crew | Atlanta United FC | 2-3 | 3 - 5 - 5 |
| 08/08/21 01:00 | 08/08/21 01:00 | Toronto FC | New York City FC | 2-2 | 5 - 5 - 3 |
| 08/08/21 01:00 | 08/08/21 01:00 | Minnesota United FC | Houston Dynamo | 2-0 | 3 - 5 - 5 |
| 08/08/21 01:30 | 08/08/21 01:30 | FC Dallas | Austin FC | 2-0 | 3 - 5 - 5 |
| 08/08/21 02:00 | 08/08/21 02:00 | Colorado Rapids | Sporting Kansas City | 0-0 | 5 - 5 - 3 |
| 08/08/21 03:30 | 08/08/21 03:30 | Portland Timbers | Real Salt Lake | 3-2 | 3 - 5 - 5 |
| 08/08/21 23:00 | 08/08/21 23:00 | Chicago Fire | New York Red Bulls | 2-1 | 4 - 5 - 4 |
| 08/08/21 23:00 | 08/08/21 23:00 | Inter Miami CF | Nashville SC | 2-1 | 4 - 5 - 3 |
| 08/08/21 23:00 | 08/08/21 23:00 | New England Revolution | Philadelphia Union | 2-1 | 3 - 5 - 5 |
| 09/08/21 00:00 | 09/08/21 00:00 | San Jose Earthquakes | Los Angeles FC | 2-1 | 4 - 5 - 3 |
| 09/08/21 01:00 | 09/08/21 01:00 | D.C. United | CF Montreal | 2-1 | 3 - 5 - 5 |
| 09/08/21 01:00 | 09/08/21 01:00 | Los Angeles Galaxy | Vancouver Whitecaps | 1-1 | 3 - 5 - 5 |