Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 05/08/21 00:00 | 05/08/21 00:00 | New England Revolution | Nashville SC | 0-0 | 3 - 5 - 5 |
| 05/08/21 00:30 | 05/08/21 00:30 | Philadelphia Union | Toronto FC | 3-0 | 3 - 5 - 5 |
| 05/08/21 00:30 | 05/08/21 00:30 | CF Montreal | Atlanta United FC | 2-2 | 4 - 5 - 4 |
| 05/08/21 00:30 | 05/08/21 00:30 | Columbus Crew | D.C. United | 2-4 | 3 - 5 - 5 |
| 05/08/21 01:00 | 05/08/21 01:00 | New York Red Bulls | Cincinnati FC | 0-0 | 3 - 5 - 5 |
| 05/08/21 01:00 | 05/08/21 01:00 | Chicago Fire | New York City FC | 0-0 | 5 - 5 - 3 |
| 05/08/21 01:00 | 05/08/21 01:00 | Orlando City | Inter Miami CF | 1-1 | 3 - 5 - 5 |
| 05/08/21 02:00 | 05/08/21 02:00 | Austin FC | Houston Dynamo | 3-2 | 4 - 5 - 4 |
| 05/08/21 03:00 | 05/08/21 03:00 | Seattle Sounders | FC Dallas | 1-1 | 3 - 5 - 5 |
| 05/08/21 03:30 | 05/08/21 03:30 | Los Angeles Galaxy | Real Salt Lake | 1-0 | 3 - 5 - 5 |
| 05/08/21 03:30 | 05/08/21 03:30 | Portland Timbers | San Jose Earthquakes | 1-1 | 3 - 5 - 5 |
| 05/08/21 03:30 | 05/08/21 03:30 | Los Angeles FC | Sporting Kansas City | 1-4 | 3 - 5 - 4 |
| 10/10/21 21:00 | 10/10/21 21:00 | Minnesota United FC | Colorado Rapids | 1-3 | 3 - 5 - 4 |