Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 29/07/21 03:30 | 29/07/21 03:30 | Los Angeles FC | Minnesota United FC | 2-2 | 3 - 5 - 5 |
| 31/07/21 00:30 | 31/07/21 00:30 | New York City FC | Columbus Crew | 4-1 | 3 - 5 - 5 |
| 31/07/21 01:00 | 31/07/21 01:00 | Orlando City | Atlanta United FC | 3-2 | 3 - 5 - 5 |
| 31/07/21 03:00 | 31/07/21 03:00 | Los Angeles Galaxy | Portland Timbers | 4-1 | 3 - 5 - 4 |
| 31/07/21 22:00 | 31/07/21 22:00 | Seattle Sounders | San Jose Earthquakes | 0-1 | 3 - 5 - 5 |
| 31/07/21 23:00 | 31/07/21 23:00 | New York Red Bulls | New England Revolution | 2-3 | 4 - 5 - 4 |
| 01/08/21 00:30 | 01/08/21 00:30 | Cincinnati FC | D.C. United | 0-0 | 4 - 5 - 4 |
| 01/08/21 01:00 | 01/08/21 01:00 | Inter Miami CF | CF Montreal | 2-1 | 4 - 5 - 4 |
| 01/08/21 01:30 | 01/08/21 01:30 | Sporting Kansas City | FC Dallas | 1-2 | 3 - 5 - 5 |
| 01/08/21 01:30 | 01/08/21 01:30 | Houston Dynamo | Real Salt Lake | 0-0 | 4 - 5 - 4 |
| 01/08/21 02:00 | 01/08/21 02:00 | Austin FC | Colorado Rapids | 0-1 | 4 - 5 - 4 |
| 01/08/21 03:00 | 01/08/21 03:00 | Vancouver Whitecaps | Minnesota United FC | 2-2 | 4 - 5 - 3 |
| 01/08/21 23:00 | 01/08/21 23:00 | Philadelphia Union | Chicago Fire | 1-1 | 3 - 5 - 5 |
| 02/08/21 00:30 | 02/08/21 00:30 | Toronto FC | Nashville SC | 1-1 | 3 - 5 - 5 |
| 05/09/21 00:00 | 05/09/21 00:00 | Vancouver Whitecaps | Austin FC | 2-1 | 3 - 5 - 5 |