Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 24/07/21 20:30 | 24/07/21 20:30 | Atlanta United FC | Columbus Crew | 0-1 | 3 - 5 - 5 |
| 25/07/21 01:00 | 25/07/21 01:00 | Chicago Fire | Toronto FC | 1-2 | 4 - 5 - 4 |
| 25/07/21 01:00 | 25/07/21 01:00 | Minnesota United FC | Portland Timbers | 2-1 | 3 - 5 - 4 |
| 25/07/21 01:30 | 25/07/21 01:30 | Nashville SC | Cincinnati FC | 3-0 | 3 - 5 - 5 |
| 25/07/21 01:30 | 25/07/21 01:30 | FC Dallas | Los Angeles Galaxy | 4-0 | 4 - 5 - 4 |
| 25/07/21 03:00 | 25/07/21 03:00 | San Jose Earthquakes | Houston Dynamo | 1-1 | 3 - 5 - 5 |
| 25/07/21 03:00 | 25/07/21 03:00 | Real Salt Lake | Colorado Rapids | 3-0 | 3 - 5 - 5 |
| 25/07/21 03:30 | 25/07/21 03:30 | Los Angeles FC | Vancouver Whitecaps | 2-2 | 3 - 5 - 5 |
| 25/07/21 23:00 | 25/07/21 23:00 | New England Revolution | CF Montreal | 2-1 | 3 - 5 - 5 |
| 25/07/21 23:00 | 25/07/21 23:00 | New York City FC | Orlando City | 5-0 | 4 - 4 - 4 |
| 26/07/21 00:30 | 26/07/21 00:30 | Inter Miami CF | Philadelphia Union | 1-1 | 5 - 5 - 3 |
| 26/07/21 01:00 | 26/07/21 01:00 | D.C. United | New York Red Bulls | 1-0 | 4 - 5 - 4 |
| 26/07/21 02:00 | 26/07/21 02:00 | Seattle Sounders | Sporting Kansas City | 1-3 | 3 - 5 - 5 |