Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| MLS | 21/05/22 20:30 | 21/05/22 20:30 | Columbus Crew | Los Angeles FC | 0-2 | 4 - 5 - 3 |
| MLS | 21/05/22 23:00 | 21/05/22 23:00 | Cincinnati FC | New England Revolution | 2-3 | 4 - 5 - 4 |
| MLS | 21/05/22 23:30 | 21/05/22 23:30 | D.C. United | Toronto FC | 2-2 | 3 - 5 - 5 |
| MLS | 22/05/22 00:30 | 22/05/22 00:30 | Nashville SC | Atlanta United FC | 2-2 | 4 - 4 - 4 |
| MLS | 22/05/22 21:00 | 22/05/22 21:00 | CF Montreal | Real Salt Lake | 1-2 | 3 - 5 - 5 |
| MLS | 22/05/22 22:00 | 22/05/22 22:00 | New York City FC | Chicago Fire | 1-0 | 3 - 5 - 5 |
| MLS | 22/05/22 22:00 | 22/05/22 22:00 | Charlotte FC | Vancouver Whitecaps | 2-1 | 3 - 5 - 5 |
| MLS | 22/05/22 23:00 | 22/05/22 23:00 | Inter Miami CF | New York Red Bulls | 2-0 | 4 - 5 - 3 |
| MLS | 23/05/22 00:00 | 23/05/22 00:00 | FC Dallas | Minnesota United FC | 1-2 | 3 - 5 - 5 |
| MLS | 23/05/22 00:30 | 23/05/22 00:30 | San Jose Earthquakes | Sporting Kansas City | 1-1 | 3 - 5 - 5 |
| MLS | 23/05/22 01:00 | 23/05/22 01:00 | Los Angeles Galaxy | Houston Dynamo | 0-3 | 3 - 5 - 5 |
| MLS | 23/05/22 01:00 | 23/05/22 01:00 | Colorado Rapids | Seattle Sounders | 1-0 | 4 - 5 - 3 |
| MLS | 23/05/22 01:00 | 23/05/22 01:00 | Austin FC | Orlando City | 2-2 | 3 - 5 - 5 |
| MLS | 23/05/22 03:00 | 23/05/22 03:00 | Portland Timbers | Philadelphia Union | 0-2 | 4 - 5 - 4 |